Jump to navigation Jump to search


Colorless, transparent liquid with an ether-like odor. Tetrahydrofuran (THF) is a strong solvent for natural and synthetic resins, especially vinyls. It is used in the manufacture of coatings, adhesives, magnetic tapes, printing inks, and Cellophane. Because THF is soluble in both water and organic solvents, it is chosen as an intermediate carrier in liquid chromatography solvent cycles.

Synonyms and Related Terms

THF; diethylene oxide; tetramethylene oxide; 1,4-epoxybutane; oxacyclopentane; Oxolane

Chemical structure



  • Flammable. Fire risk.
  • Toxic by ingestion and inhalation.
  • Skin contact may cause irritation.
  • ThermoFisher: SDS

Physical and Chemical Properties

Soluble in water and organic solvents.

Composition C4H8O
CAS 109-99-9
Melting Point -108.4 C
Density 0.888-0.889 g/ml
Molecular Weight mol. wt. = 72.11
Refractive Index 1.4070
Boiling Point 66 C


Properties of Common Solvents

Resources and Citations

  • The Merck Index, Susan Budavari (ed.), Merck Research Labs, Whitehouse Station, NJ, 12th Edition, 1996 Comment: entry 9351
  • G.G. Hawley, The Condensed Chemical Dictionary, Reinhold Publishing, New York, 6th ed., 1961
  • Van Nostrand's Scientific Encyclopedia, Douglas M. Considine (ed.), Van Nostrand Reinhold, New York, 1976

Retrieved from "https://cameo.mfa.org/index.php?title=Tetrahydrofuran&oldid=87813"